Cognitive trajectories after postoperative delirium.
Delirium is common after cardiac surgery (46% of patients in this study), and is associated with prolonged cognitive impairment.
- N=225 patients ≥60 years old (average age = 73), scheduled for coronary-artery bypass graft or valve replacement.
- Delirium assessed by Confusion Assessment Method.
- Cognitive function assessed with Mini-Mental State Examination (MMSE, score range 0-30, higher better).
- Assessments done preoperatively and daily starting on postoperative day 2 through hospitalization, then at 1, 6 and 12 months after surgery.
- Delirium developed in 103 patients (46%) after surgery.
- Delirium was associated with lower preoperative MMSE score (P<0.001):
- Delirium: 25.8
- No Delirium: 26.9
- MMSE at 1 month (P<0.001):
- Delirium: 24.1
- No Delirium: 27.4
- MMSE at 1 year (P<0.001):
- Delirium: 25.2
- No Delirium: 27.2
- After adjusting for baseline, those with delirium had significantly lower MMSE at 1 month (P<0.001) but not significantly lower at 6 months (P=0.056) or 12 months (P=0.056).
Saczynski JS, Marcantonio ER, Quach L, et al. Cognitive trajectories after postoperative delirium. N Engl J Med. 2012;367(1):30-39. doi:10.1056/NEJMoa1112923.